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structural analysis program pymol  (DeLano Scientific)

 
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    DeLano Scientific structural analysis program pymol
    Identification of P152Lp53 mutation in a patient sample and prevalence of somatic P152Lp53 missense mutations in human cancers. a, immunohistochemistry for mutant p53 by PAb240 antibody (indicated by →) on an oral cancer sample; b, sequence chromatogram showing C > T substitution at 152 position; c, location of Pro-152 (shown in pink) in 3D structure of the p53 core domain bound <t>to</t> <t>DNA</t> visualized by <t>PyMOL</t> (molecular visualization software); d, multiple sequence alignment of human TP53 protein sequence across various organisms. The Pro-152 residue is indicated by a black arrow. e, prevalence of missense mutations in a stretch of 150–155 amino acids of p53 analyzed from COSMIC database version 86; f, bar plot representation of number and frequency of various missense mutations present at TP53 (Pro-152) loci out of 111 samples of available data at COSMIC. The percentage frequency of various amino acid substitutions are shown above the bars. g, bar plot representation of number and frequency distribution of P152Lp53 mutation occurrence over various cancer tissue types out of 111 samples of P152L mutations. CNS, central nervous system, others: adrenal gland, breast, hematopoietic and lymphoid tissue, liver, lung, pancreas, skin, soft tissue, and stomach tissue.
    Structural Analysis Program Pymol, supplied by DeLano Scientific, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/structural analysis program pymol/product/DeLano Scientific
    Average 90 stars, based on 1 article reviews
    structural analysis program pymol - by Bioz Stars, 2026-03
    90/100 stars

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    1) Product Images from "The cancer-associated, gain-of-function TP53 variant P152Lp53 activates multiple signaling pathways implicated in tumorigenesis"

    Article Title: The cancer-associated, gain-of-function TP53 variant P152Lp53 activates multiple signaling pathways implicated in tumorigenesis

    Journal: The Journal of Biological Chemistry

    doi: 10.1074/jbc.RA118.007265

    Identification of P152Lp53 mutation in a patient sample and prevalence of somatic P152Lp53 missense mutations in human cancers. a, immunohistochemistry for mutant p53 by PAb240 antibody (indicated by →) on an oral cancer sample; b, sequence chromatogram showing C > T substitution at 152 position; c, location of Pro-152 (shown in pink) in 3D structure of the p53 core domain bound to DNA visualized by PyMOL (molecular visualization software); d, multiple sequence alignment of human TP53 protein sequence across various organisms. The Pro-152 residue is indicated by a black arrow. e, prevalence of missense mutations in a stretch of 150–155 amino acids of p53 analyzed from COSMIC database version 86; f, bar plot representation of number and frequency of various missense mutations present at TP53 (Pro-152) loci out of 111 samples of available data at COSMIC. The percentage frequency of various amino acid substitutions are shown above the bars. g, bar plot representation of number and frequency distribution of P152Lp53 mutation occurrence over various cancer tissue types out of 111 samples of P152L mutations. CNS, central nervous system, others: adrenal gland, breast, hematopoietic and lymphoid tissue, liver, lung, pancreas, skin, soft tissue, and stomach tissue.
    Figure Legend Snippet: Identification of P152Lp53 mutation in a patient sample and prevalence of somatic P152Lp53 missense mutations in human cancers. a, immunohistochemistry for mutant p53 by PAb240 antibody (indicated by →) on an oral cancer sample; b, sequence chromatogram showing C > T substitution at 152 position; c, location of Pro-152 (shown in pink) in 3D structure of the p53 core domain bound to DNA visualized by PyMOL (molecular visualization software); d, multiple sequence alignment of human TP53 protein sequence across various organisms. The Pro-152 residue is indicated by a black arrow. e, prevalence of missense mutations in a stretch of 150–155 amino acids of p53 analyzed from COSMIC database version 86; f, bar plot representation of number and frequency of various missense mutations present at TP53 (Pro-152) loci out of 111 samples of available data at COSMIC. The percentage frequency of various amino acid substitutions are shown above the bars. g, bar plot representation of number and frequency distribution of P152Lp53 mutation occurrence over various cancer tissue types out of 111 samples of P152L mutations. CNS, central nervous system, others: adrenal gland, breast, hematopoietic and lymphoid tissue, liver, lung, pancreas, skin, soft tissue, and stomach tissue.

    Techniques Used: Mutagenesis, Immunohistochemistry, Sequencing, Software, Residue



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    structural analysis program pymol  (DeLano Scientific)
    90
    DeLano Scientific structural analysis program pymol
    Identification of P152Lp53 mutation in a patient sample and prevalence of somatic P152Lp53 missense mutations in human cancers. a, immunohistochemistry for mutant p53 by PAb240 antibody (indicated by →) on an oral cancer sample; b, sequence chromatogram showing C > T substitution at 152 position; c, location of Pro-152 (shown in pink) in 3D structure of the p53 core domain bound <t>to</t> <t>DNA</t> visualized by <t>PyMOL</t> (molecular visualization software); d, multiple sequence alignment of human TP53 protein sequence across various organisms. The Pro-152 residue is indicated by a black arrow. e, prevalence of missense mutations in a stretch of 150–155 amino acids of p53 analyzed from COSMIC database version 86; f, bar plot representation of number and frequency of various missense mutations present at TP53 (Pro-152) loci out of 111 samples of available data at COSMIC. The percentage frequency of various amino acid substitutions are shown above the bars. g, bar plot representation of number and frequency distribution of P152Lp53 mutation occurrence over various cancer tissue types out of 111 samples of P152L mutations. CNS, central nervous system, others: adrenal gland, breast, hematopoietic and lymphoid tissue, liver, lung, pancreas, skin, soft tissue, and stomach tissue.
    Structural Analysis Program Pymol, supplied by DeLano Scientific, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/structural analysis program pymol/product/DeLano Scientific
    Average 90 stars, based on 1 article reviews
    structural analysis program pymol - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Identification of P152Lp53 mutation in a patient sample and prevalence of somatic P152Lp53 missense mutations in human cancers. a, immunohistochemistry for mutant p53 by PAb240 antibody (indicated by →) on an oral cancer sample; b, sequence chromatogram showing C > T substitution at 152 position; c, location of Pro-152 (shown in pink) in 3D structure of the p53 core domain bound to DNA visualized by PyMOL (molecular visualization software); d, multiple sequence alignment of human TP53 protein sequence across various organisms. The Pro-152 residue is indicated by a black arrow. e, prevalence of missense mutations in a stretch of 150–155 amino acids of p53 analyzed from COSMIC database version 86; f, bar plot representation of number and frequency of various missense mutations present at TP53 (Pro-152) loci out of 111 samples of available data at COSMIC. The percentage frequency of various amino acid substitutions are shown above the bars. g, bar plot representation of number and frequency distribution of P152Lp53 mutation occurrence over various cancer tissue types out of 111 samples of P152L mutations. CNS, central nervous system, others: adrenal gland, breast, hematopoietic and lymphoid tissue, liver, lung, pancreas, skin, soft tissue, and stomach tissue.

    Journal: The Journal of Biological Chemistry

    Article Title: The cancer-associated, gain-of-function TP53 variant P152Lp53 activates multiple signaling pathways implicated in tumorigenesis

    doi: 10.1074/jbc.RA118.007265

    Figure Lengend Snippet: Identification of P152Lp53 mutation in a patient sample and prevalence of somatic P152Lp53 missense mutations in human cancers. a, immunohistochemistry for mutant p53 by PAb240 antibody (indicated by →) on an oral cancer sample; b, sequence chromatogram showing C > T substitution at 152 position; c, location of Pro-152 (shown in pink) in 3D structure of the p53 core domain bound to DNA visualized by PyMOL (molecular visualization software); d, multiple sequence alignment of human TP53 protein sequence across various organisms. The Pro-152 residue is indicated by a black arrow. e, prevalence of missense mutations in a stretch of 150–155 amino acids of p53 analyzed from COSMIC database version 86; f, bar plot representation of number and frequency of various missense mutations present at TP53 (Pro-152) loci out of 111 samples of available data at COSMIC. The percentage frequency of various amino acid substitutions are shown above the bars. g, bar plot representation of number and frequency distribution of P152Lp53 mutation occurrence over various cancer tissue types out of 111 samples of P152L mutations. CNS, central nervous system, others: adrenal gland, breast, hematopoietic and lymphoid tissue, liver, lung, pancreas, skin, soft tissue, and stomach tissue.

    Article Snippet: To model the location of proline at position 152 of p53, coordinates of the human p53 DNA-binding domain bound to DNA with accession code 1TUP, tumor suppressor p53 complexed with DNA were taken from RCSB, and analyzed with the structural analysis program PyMOL (DeLano Scientific, Palo Alto, CA).

    Techniques: Mutagenesis, Immunohistochemistry, Sequencing, Software, Residue